CLIA Certified Genetic Testing
EpigenDx performs diagnostic tests that report on a patient’s genotype or methylation profile. Our tests are validated for CLIA testing. If you are a physician and would like to know more, please contact us.
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|ADS747||KRAS Mutation Test||Inquiry / Order|
|ADS167||LINE-1 Methylation Test||Inquiry / Order|
|ASY514||MGMT Methylation Test||Inquiry / Order|
|ADS783||FOXP3 Methylation Test||Inquiry / Order|
List of Diagnostic Tests
KRAS Mutation Test
This test is an LDT pyrosequencing test that detects seven common KRAS mutations in colorectal cancer patients. The test indicates which patients with metastatic colorectal cancer may benefit from anti-EGFR drugs, such as ERBITUX. We accept formalin-fixed paraffin embedded (FFPE) tissue sections or isolated DNA for diagnostic testing.
LINE-1 Methylation Test
This test detects methylation levels in the LINE-1 transposable element. The LINE test can be used to monitor a patient’s response to demethylating agents. The methylation of LINE-1 elements is an indicator of genomic instability. Researchers have reported that low methylation levels are associated with the erratic copying and transposing of unmethylated LINE-1 elements across the genome, resulting in many malignancies.
MGMT Methylation Test
This test detects methylation levels in the MGMT promoter of glioblastoma patients, which indicates a patient’s responsiveness to alkylating chemotherapy.
FOXP3 Methylation Test
This test detects methylation of the FOXP3 gene, which is the master regulator of regulatory T-cell or Treg differentiation. This information is helpful in diagnosing certain autoimmune diseases or predicting a cancer patient’s response to immunotherapy.